radiograph is normal. Several fundamental aspects of the natural history and treatment of ltbi in children must be considered when making recommendations about therapy. In the clinical trials involving HIV-infected persons, a trend of increased adverse reactions occurred among persons taking a daily regimen that included pyrazinamide. Prevention of experimental tuberculosis with isoniazid. Tests should be read 48-72 h after test administration, and the transverse diameter of induration should be recorded in millimeters. Serious adverse events include those associated with hospitalization, permanent disability, or death. However, several rifamycin derivatives with half-lives substantially greater than rifampin are of interest because of the possibility of widely spaced, intermittent administration. The multinational study reported minimal increases in the number of persons receiving the 2-mo rifampin and pyrazinamide regimen who had the drugs permanently discontinued, most commonly because of nausea and vomiting and narcotic withdrawal ( 111 ). Finally, epidemiologic research to determine the best tools to identify children at high risk for ltbi should be undertaken. If it is not possible to provide DOT to enhance adherence with treatment of ltbi, the prescribed regimen should be incorporated into patients' daily routines. Thus, although pyrazinamide may be considered after the first trimester in women with HIV infection ( 142 it should otherwise be avoided.
No interruptions during medication administration thesis statement
University of Minnesota School of Public Health Minneapolis, MN Noreen. In a recent meta-analysis of placebo-controlled trials, adverse drug reactions were slightly but not significantly more common among persons receiving isoniazid ( 88 ). However, studies conducted in the late 1960s suggested that isoniazid did cause hepatitis and indicated that asymptomatic increase in hepatic transaminases occurred among persons receiving the drug ( 89 ). The preferred skin test for. An original paper copy of this issue can be obtained from the Superintendent of Documents,.S. Silicosis in northern Rhodesia copper miners. A repeat chest film should be obtained to exclude active TB, as indicated by improvement in the abnormality even in the presence of negative cultures.